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KMID : 0876319990010010029
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Cachon Medical Journal
1999 Volume.1 No. 1 p.29 ~ p.33
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Reflux As an Etiologic Factor in Laryngo Pharyngeal Cancer
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Jang Il-Hwan
Seok Youn-Sik
Kim Seon-Tae
Kim Chan-Woo
Cha Heung-Eog
Park Byung-Hoon
Oh Seung-Chul
Hyung Bong-Seung
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Abstract
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Purpose: Several forms of laryngeal dysfunction and pathology can be attributed to the effects of laryngopharyngeal reflux(LPR) through direct acid irritation. It is widely accepted that contact ulcers and granulomata over the arytenoid are associated with LPR, but there have not been well-documented that laryngopharyngeal carcinoma are related with reflux. The purpose of this study is to determine the relationship between laryngopharyngeal carcinoma and LPR as causative factor.
Materials and Methods: Over a two-year period, a prospective study of sixteen patients with carcinoma of the laryngopharynx was carried out. Prior to therapy including surgery and radiation therapy, each patient underwent esophageal manometry and ambulatory 24-hour double-probe pH monitoring.
Results: Eleven of the 16 patients(68%) had laryngopharyngeal reflux, that is, abnormal reflux in the pharyngeal probe. The total fraction time pH<4.0 for the study population in the pharyngeal probe was 1.3±2.4%(1.5±2.9% in the upright position, and 1.0±2.6% in the supine position). In according to tumor site, LPR was present at 83% in glottis, 74% in hypopharynz, 50% in supraglottis.
Conclusion: A multifactorial theory of laryngopharyngeal carcinogenesis is presented. LPR appears to be a significant risk cofactor for the development of laryngopharyngeal carcinoma.
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KEYWORD
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Laryngopharyngeal carcinoma, Laryngopharyngeal reflux
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